Thursday April 8th
Welcome Remarks with Dr. Ana Andreazza, Scientific Director, MITO2i.
Opening Remarks with Dr. Christine Allen, Associate Vice-President and Vice-Provost Strategic Initiatives University of Toronto.
Keynote Speaker: "Targeting the cellular metabolism to treat tissue-specific mitochondrial diseases”
Dr. Rita Horvath MD, PhD. Director of Research (Clinical) - Genetics of Rare Neurological Disorders Department of Clinical Neurosciences,
University of Cambridge, John Van Geest Cambridge Centre for Brain Repair
Break.
Introduction of Innovation Grant Awardees by Sonya Brijbassi, Associate Director Strategy & Partnerships MITO2i.
Quick Fire Talks from the Innovation Grant Awardees:
Moderator: Dr. Ben Goldstein
Professor of Psychiatry and Pharmacology Director, Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health.
Dr. Robert Screaton, Senior Scientist Sunnybrook Research Institute
Mitochondrial Metabolism Vulnerabilities in Breast Cancer:
Dr. Ingrid Tein, Director, Neurometabolic Clinic, Hospital for Sick Children
Identification of candidate genetic susceptibility variants in the carnitine transporter and carnitine biosynthesis gene families in Autism Spectrum Disorder: A novel precision medicine target
Dr. Walid Houry, Professor, Department of Biochemistry, University of Toronto
Investigation of the role of ClpP protease deficiency in Perrault syndrome with Leukodystrophy.
Dr. Laura Rosella, Associate Professor, Dalla Lana School of Public Health, U of T
The epidemiology and health system impact of mitochondrial disease and psychiatric conditions in Ontario: A population-based study.
Dr. Alessandro Colasanti, Senior Clinical Lecturer - Psychiatry; Brighton and Sussex Medical School
Neuropsychiatric and Brain Imaging Phenotyping of primary Mitochondrial Diseases
Break.
Industry Speaker - Dr. Herma Renkema,
Chief Early Development Officer Khondrion
“Path From Research to Clinical Trials for Lead Compound Sonlicromanol (KH176)"
Closing Remarks for Day One.
- MitoFutures Trainee Development and Networking Hour -
Inviting all undergraduates, graduate students, postdoctoral fellows and PI's to learn how to apply AI to your own research and explore future opportunities in the field.
Guest Speaker: David Dai, Senior Data Scientist, St. Michael’s Hospital as part of Unity Health, Temerty Centre for AI Research and Education in Medicine
Note: The MitoFurtures Trainee Development and Networking Hour requires a separate registration from the symposium.
Friday April 9th
Welcome & Introduction of Fellows and Thomas Zachos Scholars with:
Blaine Penny (Member of the Board Director & Co-Founder Mitocanada Foundation)
and
Thomas Zachos (Patient Advocate & MITO2i Supporter).
Quick fire talks from the mitoFUTURES Fellows and Scholars, with Moderator Dr. Ruth Slack Professor University of Ottawa.
Jessika Royea - Departments of Biochemistry, Cellular and Molecular Medicine, Microbiology & Immunology University of Ottawa
Sigma-1 receptors as therapeutic targets for mitochondrial
dysfunction
Minesh Kapadia - Department of Surgery Toronto Western Hospital, UHN, University of Toronto
Regulation of PINK1-Parkin Mitophagy by Molecular Chaperones
Mohamed Ariff Iqbal - Department of Cellular and Molecular Medicine
University of Ottawa
The importance of mitochondrial dynamics in maintenance of neural stem cell function
Aleksandra Marakhovskaia - Department of Pharmacology & Toxicology
University of Toronto
Establishing a novel role of mental illnesses associated gene, Fxr1in regulation of mitochondrial function in cortical neurons. Potential relevance for the mitochondrial function dysregulation in psychiatric disorders.
Aadil Ali - Toronto General Hospital, UHN, University of Toronto
Manipulation of Organ temperature and Metabolism for the
Extension of Donor Lung Preservation Times
Sanna Masud - Department of Molecular Genetics University of Toronto
Mapping the genetic interactions of TAZ: towards a functional wiring diagram of the mitochondrion
David Bodenstein - Department of Pharmacology & Toxicology University of Toronto
Novel approaches to eliminate mutant mitochondrial DNA and transplantation in patient-derived induced-pluripotent stem cells
Swathi Jeedigunta - Department of Molecular Genetics University of Toronto
Determining the role of PolG1 in eliminating deleterious mitochondrial DNA from the female germline
Panel Session: Mitochondria Highlights: Ophthalmology:
Dr. Ana Andreazza
Moderator - Scientific Director of MITO2i
Assistant Professor and Vie-Chair Research, Department of Ophthalmology University of Ottawa
Professor Department of Ophthalmology & Vision Sciences
University Health Network (UHN)
University Professor Canada Research Chair in Tissue Engineering Department of Applied Chemistry and Chemical Engineering U of T.
Break.
Mitochondria Highlights: Organ Biology
Chief, Anesthesia and Pain Medicine, Curtis Joseph and Harold Groves Chair in Anesthesia and Pain Medicine, Department of Anesthesia and Pain Medicine, Hospital for Sick Children
Dr. Isabella Cannigia -
Assistant Professor, Department of Physiology University of Toronto Investigator, LTRI, Mount Sinai
Announcement MITO2i and Toronto Dementia Research Alliance (TDRA) Partnership.
MITO2i Trainee 60 – 90 second Videos
Remarks by Dr. Reinhart Reithmeier
Final Thank-you and Closing – MITO2i Team.