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MITO2i is pleased to announced that it will be holding its 2nd Annual Research Symposium on April 28th & 29th and is thrilled to showcase new and exciting areas for mitochondrial research and medicine. Over the two days we will be highlighting:

  • Mitochondria and Metabolism with a focus on Diabetes and Cardiovascular Health

  • The importance of Mitochondria function in Organ Transplantation.

  • Mitogenetics and Brain disease looking at research in Parkinson’s and Dementia

  • An introduction to Mito Innovation from UofT start-up companies, new areas for mitochondria targeting and the potential of using AI to identify mitochondrial gene risk.

The Symposium is a great opportunity to stay up to date in the field of mitochondrial research and to seek potential collaboration areas with MITO2i and the community! We hope to see you there.

Day 1: April 28th

10:00am

Opening Remarks:  Dr. Ana Andreazza, Scientific Director, MITO2i

10:10am

An Introduction to Diabetes Research

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10:20am

Variable energetic efficiency in mitochondria, and implications for metabolic diseases

Dr. Mary-Ellen Harper 
Professor, University Research Chair in Mitochondrial Bionergetics, Director, Ottawa Institute of Systems Biology, University of Ottawa

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11:00am

MITO2i 2022 Graduate Student Scholarship Awardees:

 

The implications of dietary intervention on mitochondrial dysfunction in type 2 diabetes

Kassandra Zachos, PhD Candidate, Department of Pharmacology & Toxicology, University of Toronto

Elucidating the role of mitochondrial dysfunction in pancreatic endothelial cells in type 1 diabetes

 Safwat Khan, PhD Candidate, Department of Laboratory Medicine and Pathobiology, University of Toronto

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11:20am

An introduction to Cardiac Research and Mitochondrial Dysfunction

 

Professor Milica Radisic

Canada Research Chair, Functional Cardiovascular Tissue Engineering. Associate Chair, Research, Department of Chemical Engineering & Applied Chemistry

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11:30am

A mitochondiropathy in COVID-19 pneumonia: SARS-CoV-2 induced apoptosis and impairment of oxygen sensing underlies hypoxemia

Dr. Stephen L. Archer MD. FRCP(C), FRSC, FAHA, FACC

Tier 1 CRC Mitochondrial Dynamics
Elizabeth Smith Distinguished University Professor C. Franklin and Helene K. Bracken Chair, Head Department of Medicine, Queen's University

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12:00pm

MITO2i Graduate Student Scholarship Awardees:

 

Assessing mitochondrial dysfunction due to SARS-CoV-2 infection in a heart-on-a-chip platform

Jacob Smith: PhD Candidate, Department of Department of Chemical Engineering & Applied Chemistry, University of Toronto

Mitochondrial and Metabolic Therapies for Heart Disease Based on the Regenerative Potential of the Pediatric Heart

Fatemeh Mirshafiei , PhD Candidate, Department of Biochemistry, Faculty of Medicine University of Toronto

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12:20pm - 12:40pm

Lunch Break

12:40pm

Introduction to Mitochondria role in Organ Transplant:

Moderated discussion with Dr. Ana Andreazza, Scientific Director, MITO2i

PANELISTS:

Dr. Marcelo Cypel, Thoracic Surgeon at University Health Network (UHN) and Professor of Surgery at the University of Toronto

 

Dr. Ori Rotstein, Vice President of Research and Innovation at Unity Health Toronto. Professor and Associate Chair of the Department of Surgery at the University of Toronto.

Ana Konvalinka MD, PhD, FRCPC: Transplant Nephrologist, Clinician Scientist, Department of Medicine, Division of Nephrology, University Health Network Director, Multi-organ Transplant Biobank, Ajmera Transplant Centre Scientist, Toronto General Hospital Research Institute

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1:30pm

MITO2i Graduate Student Scholarship Awardees:

 

Investigating the Relationship between the Mitochondria and Lung Transplant Success

Erika Beroncal, Masters Candidate, Department of Pharmacology & Toxicology University of Toronto

Mitochondrial Transplantation to Lessen Hepatic Ischemia/Reperfusion Injury: Efficacy, Mechanisms, & Translation

Avinash Mukkala, PhD Candidate, Keenan Research Centre for Biomedical Science, Unity Health Toronto, Institute of Medical Science, University of Toronto

 

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1:55pm

Closing Remarks.

2:00pm - 3:00pm

Special Trainee Session – Mitochondrial Technologies

Chris Perry, Associate Professor

School of Kinesiology and Health Science
Muscle Health Research Centre, 
York University

Invite only Industry Collaboration Event

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Day 2: April 29th

10:00am

Opening Remarks:  Dr. Ana Andreazza, Scientific Director, MITO2i

10:05am

Introduction to Brain and Mitogenetics

Dr. Susan George
Professor of Medicine and Pharmacology & Toxicology at the University of Toronto, and a Clinician Scientist in the Division of Endocrinology at Toronto General Hospital, University Health Network

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10:15am

Energy, Mitochondria, and the Brain-Body Connection

Dr. Martin Picard, Associate Professor of Behavioral Medicine (in Psychiatry and Neurology) at Columbia University Irving Medical Center

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10:55am

MITO2i Graduate Student Scholarship Awardees:

 

Identifying probiotics that modulate mitophagy in models of mitochondrial dysfunction: Gao, Jinghua, PhD Candidate, Department of Biochemistry, UofT

C-terminus of HSP70 Interacting Protein in Mitochondrial Quality Control: Rebecca Earnshaw, PhD Candidate, Department of Surgery, UofT

Mitochondrial dysfunction and cognitive improvements in cognitively impaired patients undergoing exercise-primed anodal transcranial direct current stimulation (AtDCS)

(Ella) Bing Xin Song, PhD Candidate, Department of Pharmacology & Toxicology University of Toronto

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11:25am

Application of Experimental and AI Approaches Toward Drug Discovery for Parkinson's Disease:

Rosetta Therapeutics Inc. -  Peter N. Lewis, CEO

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11:55am - 12:15pm

Lunch Break.

12:15pm

Introduction to Mitochondria and Genetics:

Dr. Vanessa Goncalves, Independent Scientist, CAMH

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12:20pm

MITO2i Graduate Student Scholarship Awardees:

 

Guanine Quadruplex Structures in Mitochondria Health and Disease

Melissa Geng PhD. Candidate, Department of Pediatrics and Molecular Genetics · The Hospital for Sick Children

Charaterizing mitochondrialfunciton and morphology in mouse models with GRINl patient varients

Yuanye Yan, PhD Candidate, Department of Pharmacology & Toxicology, University of Toronto

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12:40pm

Bringing microbiology principles to population pharmacogenetics for mitochondrial disorders
 

Katheron Inston

CEO of Varient - A UofT Start-up Company

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1:00pm

AI and Mitochondrial Data:
 

Jaehyoung Choi, PhD candidate, Department of Pharmacology & Toxicology

 

Dr. Joseph Geraci, PhD, CSO at Nurosene Inc, Chief AI Scientist at NetraMark Corp. Associate Professor in Molecular Medicine Queen's University, CAD

 

Kate Murray

CEO MitoCanada

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1:20pm

Targeting Mitochondria
 

Metabolomics and transcriptomics analysis of the evolution of
chemoresistance in breast cancer

Dr. Julie St-Pierre. Professor Department of Biochemistry, Microbiology and Immunology Ottawa Institute of Systems Biology Faculty of Medicine, University of Ottawa

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1:50pm

MITO2i Graduate Student Scholarship Awardees:

 

Understanding mitochondrial protease ClpXP degradation machinery
and its function in acute myeloid leukemia

Yue Feng, PhD candidate, Departments of Medical Biophysics, University of Toronto

Human embryo mtDNA heteroplasmy dynamics and clinical significance of mtDNA variation in pre-implantation embryos from fertile and infertile populations

Ana Novaselska, Masters Candidate, University of Toronto, Department of Physiology

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2:15pm

Closing Remarks.